Details

Autor(en) / Beteiligte

• Grirrane, Abdessamad
• Álvarez, Eleuterio
• García, Hermenegildo
• Corma, Avelino

Titel

Deactivation of Cationic CuI and AuI Catalysts for A3 Coupling by CH2Cl2: Mechanistic Implications of the Formation of Neutral CuI and AuI Chlorides

Ist Teil von

• Angewandte Chemie (International ed.), 2014-07, Vol.53 (28), p.7253-7258

Auflage

International ed. in English

Ort / Verlag

Weinheim: WILEY-VCH Verlag

Erscheinungsjahr

2014

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Care should be exercised when using CH2Cl2 as a solvent for reactions in which amines are a reagent, since undesirable deactivation of cationic copper(I) and gold(I) catalysts to form the corresponding inactive neutral chloride complexes [LMCl] (M=Cu or Au) can occur as a result of the generation of hydrogen chloride in the medium. CuI and AuI deactivation has been proved for the Mannich three‐component coupling reaction. A series of CuI and AuI complexes with potential mechanistic implications were isolated and characterized by X‐ray crystallography. Proceed with caution! Care should be exercised when using CH2Cl2 as a solvent for reactions in which amines are a reagent, since undesirable deactivation of cationic CuI and AuI catalysts to form the corresponding inactive neutral chloride complexes [LMCl] (M=Cu or Au) can occur as a result of the generation of hydrogen chloride in the medium. This phenomenon was studied on the basis of a Mannich three‐component coupling reaction (see scheme).