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Ferns and Lycopods—A Potential Treasury of Anticancer Agents but Also a Carcinogenic Hazard
Phytotherapy research, 2014-06, Vol.28 (6), p.798-810
Tomsik, Pavel
2014
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Tomsik, Pavel
Titel
Ferns and Lycopods—A Potential Treasury of Anticancer Agents but Also a Carcinogenic Hazard
Ist Teil von
Phytotherapy research, 2014-06, Vol.28 (6), p.798-810
Ort / Verlag
England: J. Wiley
Erscheinungsjahr
2014
Quelle
Wiley Online Library All Journals
Beschreibungen/Notizen
Many species of seedless vascular plants—ferns and lycopods—have been used as food and folk medicine since ancient times. Some of them have become the focus of intensive research concerning their anticancer properties. Studies on the anticancer effect of crude extracts are being increasingly replaced by bioactivity‐guided fractionation, as well as detailed assessment of the mechanism of action. Numerous compounds—especially flavonoids such as amentoflavone and protoapigenone, and also simpler phenolic compounds, steroids, alkaloids and terpenoids—were isolated and found to be cytotoxic, particularly pro‐apoptotic, or to induce cell cycle arrest in cancer cell lines in vitro. In in vivo experiments, some fern‐derived compounds inhibited tumour growth with little toxicity. On the other hand, many ferns—not only the well‐known Bracken (Pteridium)—may pose a significant hazard to human health due to the fact that they contain carcinogenic sesquiterpenoids and their analogues. The objective of this review is to summarise the recent state of research on the anticancer properties of ferns and lycopods, with a focus on their characteristic bioactive constituents. The carcinogenic hazard posed by ferns is also mentioned. Copyright © 2013 John Wiley & Sons, Ltd.
Sprache
Englisch
Identifikatoren
ISSN: 0951-418X
eISSN: 1099-1573
DOI: 10.1002/ptr.5070
Titel-ID: cdi_proquest_journals_1532961072
Format
–
Schlagworte
alkaloids
,
Animals
,
anticarcinogenic activity
,
antineoplastic agents
,
Antineoplastic Agents, Phytogenic - chemistry
,
cancer
,
carcinogenicity
,
Carcinogens - chemistry
,
cell cycle
,
Cell Line
,
ferns
,
Ferns - chemistry
,
ferns and fern allies
,
Flavonoids - chemistry
,
foods
,
fractionation
,
human health
,
Humans
,
in vivo studies
,
Lycopodiaceae - chemistry
,
lycopods
,
mechanism of action
,
phenolic compounds
,
Phenols - chemistry
,
Pteridium
,
Pteridium - chemistry
,
sesquiterpenoids
,
steroids
,
Terpenes - chemistry
,
traditional medicine
,
vascular plants
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