Details

Autor(en) / Beteiligte

• Sun, Zhan-Fang
• Xiang, Xiao-Shuang
• Chen, Zhao
• Zhang, Li
• Tang, Bei-Sha
• Xia, Kun
• Jiang, Hong

Titel

Increase of the plasma [alpha]-synuclein levels in patients with multiple system atrophy

Ist Teil von

• Movement disorders, 2014-03, Vol.29, p.375

Ort / Verlag

Hoboken: Wiley Subscription Services, Inc

Erscheinungsjahr

2014

Quelle

Wiley Online Library - AutoHoldings Journals

Beschreibungen/Notizen

• Multiple system atrophy, a sporadic neurodegenerative disease, is characterized by the presence of high numbers of glial cytoplasmic inclusions mainly formed by [alpha]-synuclein protein, which is encoded by the SNCA gene. To date, however, few studies have investigated the plasma [alpha]-synuclein levels in patients with multiple system atrophy. We studied plasma [alpha]-synuclein concentrations by using an enzyme-linked immunosorbent assay in 74 patients with multiple system atrophy and 90 healthy controls. The plasma [alpha]-synuclein levels were significantly elevated in patients who had multiple system atrophy compared with the control group (P=0.000). In a subgroup of 48 patients who had probable multiple system atrophy, there was a weakly negative correlation between plasma [alpha]-synuclein levels and subscores on Unified Multiple System Atrophy Rating Scale item VI (rs=-0.307; P=0.034). Plasma [alpha]-synuclein levels were elevated in patients with multiple system atrophy, and these levels may be decreased with the development of disease. © 2013 International Parkinson and Movement Disorder Society. [PUBLICATION ABSTRACT]