Details

Autor(en) / Beteiligte

• von Tiehl, Karl F., MD
• Price, Matthew J., MD, FACC
• Valencia, Rafael, MD
• Ludington, Katherine J., MD, FACC
• Teirstein, Paul S., MD, FACC
• Simon, Ronald A., MD

Titel

Clopidogrel Desensitization After Drug-Eluting Stent Placement

Ist Teil von

• Journal of the American College of Cardiology, 2007-11, Vol.50 (21), p.2039-2043

Ort / Verlag

New York, NY: Elsevier Inc

Erscheinungsjahr

2007

Quelle

MEDLINE

Beschreibungen/Notizen

• Clopidogrel Desensitization After Drug-Eluting Stent Placement Karl F. von Tiehl, Matthew J. Price, Rafael Valencia, Katherine J. Ludington, Paul S. Teirstein, Ronald A. Simon Adverse reactions to clopidogrel are not uncommon and, after drug-eluting stent placement, affected patients must switch to ticlopidine despite its more malignant side-effect profile because of the risk of ischemic events associated with premature discontinuation of dual antiplatelet therapy. We enrolled 24 consecutive patients with suspected allergic reactions to clopidogrel after drug-eluting stent implantation, 20 of whom were outpatients. Desensitization was acutely successful in all patients. Clopidogrel desensitization is safe and effective, induces a sustained remission, and could be advantageous in treating outpatients who are at-risk for premature discontinuation of dual antiplatelet therapy.