Details

Autor(en) / Beteiligte

• Stevenson, Donald D.
• Szczeklik, Andrew

Titel

Clinical and pathologic perspectives on aspirin sensitivity and asthma

Ist Teil von

• Journal of allergy and clinical immunology, 2006-10, Vol.118 (4), p.773-786

Ort / Verlag

New York, NY: Mosby, Inc

Erscheinungsjahr

2006

Quelle

MEDLINE

Beschreibungen/Notizen

• Aspirin and other nonsteroidal anti-inflammatory drugs that inhibit COX-1 induce unique nonallergic reactions, consisting of attacks of rhinitis and asthma. These hypersensitivity reactions occur in a subset of asthmatic subjects, thus identifying them as having this exclusive clinical presentation. We refer to these patients as having aspirin-exacerbated respiratory disease, a disease process that produces devastating eosinophilic inflammation of both the upper and lower respiratory tracts. This review focuses on a description of patients with aspirin-exacerbated respiratory disease, methods available to diagnose their condition, the unique ability of all nonsteroidal anti-inflammatory drugs that inhibit COX-1 to cross-react with aspirin, an update on pathogenesis, and current thoughts about treatment.