Details

Autor(en) / Beteiligte

• Hall, Aisling O'Hara
• Beiting, Daniel P
• Tato, Cristina
• John, Beena
• Oldenhove, Guillaume
• Lombana, Claudia Gonzalez
• Pritchard, Gretchen Harms
• Silver, Jonathan S
• Bouladoux, Nicolas
• Stumhofer, Jason S
• Harris, Tajie H
• Grainger, John
• Wojno, Elia D Tait
• Wagage, Sagie
• Roos, David S
• Scott, Philip
• Turka, Laurence A
• Cherry, Sara
• Reiner, Steven L
• Cua, Daniel
• Belkaid, Yasmine
• Elloso, M Merle
• Hunter, Christopher A

Titel

The Cytokines Interleukin 27 and Interferon-[gamma] Promote Distinct Treg Cell Populations Required to Limit Infection-Induced Pathology

Ist Teil von

• Immunity (Cambridge, Mass.), 2012-09, Vol.37 (3), p.511

Ort / Verlag

Cambridge: Elsevier Limited

Erscheinungsjahr

2012

Link zum Volltext

Quelle

Elsevier ScienceDirect Journals Complete

Beschreibungen/Notizen

• Interferon-γ (IFN-γ) promotes a population of T-bet+CXCR3+regulatory T (Treg) cells that limit T helper 1 (Th1) cell-mediated pathology. Our studies demonstrate that interleukin-27 (IL-27) also promoted expression of T-bet and CXCR3 in Treg cells. During infection withToxoplasma gondii, a similar population emerged that limited T cell responses and was dependent on IFN-γ in the periphery but on IL-27 at mucosal sites. Transfer of Treg cells ameliorated the infection-induced pathology observed inIl27-/-mice, and this was dependent on their ability to produce IL-10. Microarray analysis revealed that Treg cells exposed to either IFN-γ or IL-27 have distinct transcriptional profiles. Thus, IFN-γ and IL-27 have different roles in Treg cell biology and IL-27 is a key cytokine that promotes the development of Treg cells specialized to control Th1 cell-mediated immunity at local sites of inflammation.