Details

Autor(en) / Beteiligte

• Szanto, Attila
• Balint, Balint L
• Nagy, Zsuzsanna S
• Barta, Endre
• Dezso, Balazs
• Pap, Attila
• Szeles, Lajos
• Poliska, Szilard
• Oros, Melinda
• Evan s, Ronald M
• Barak, Yaacov
• Schwabe, John
• Nagy, Laszlo

Titel

STAT6 Transcription Factor Is a Facilitator of the Nuclear Receptor PPAR[gamma]-Regulated Gene Expression in Macrophages and Dendritic Cells

Ist Teil von

• Immunity (Cambridge, Mass.), 2010-11, Vol.33 (5), p.699

Ort / Verlag

Cambridge: Elsevier Limited

Erscheinungsjahr

2010

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Peroxisome proliferator-activated receptor γ (PPARγ) is a lipid-activated transcription factor regulating lipid metabolism and inflammatory response in macrophages and dendritic cells (DCs). These immune cells exposed to distinct inflammatory milieu show cell type specification as a result of altered gene expression. We demonstrate here a mechanism how inflammatory molecules modulate PPARγ signaling in distinct subsets of cells. Proinflammatory molecules inhibited whereas interleukin-4 (IL-4) stimulated PPARγ activity in macrophages and DCs. Furthermore, IL-4 signaling augmented PPARγ activity through an interaction between PPARγ and signal transducer and activators of transcription 6 (STAT6) on promoters of PPARγ target genes, includingFABP4. Thus, STAT6 acts as a facilitating factor for PPARγ by promoting DNA binding and consequently increasing the number of regulated genes and the magnitude of responses. This interaction, underpinning cell type-specific responses, represents a unique way of controlling nuclear receptor signaling by inflammatory molecules in immune cells.