Details

Autor(en) / Beteiligte

• Scotet, Emmanuel
• Martinez, Laurent O
• Grant, Ethan
• Barbaras, Ronald
• Jenö, Paul
• Guiraud, Martine
• Monsarrat, Bernard
• Saulquin, Xavier
• Maillet, Sophie
• Estève, Jean-Pierre
• Lopez, Frédéric
• Perret, Bertrand
• Collet, Xavier
• Bonneville, Marc
• Champagne, Eric

Titel

Tumor Recognition following V[gamma]9V[delta]2 T Cell Receptor Interactions with a Surface F1-ATPase-Related Structure and Apolipoprotein A-I

Ist Teil von

• Immunity (Cambridge, Mass.), 2005-01, Vol.22 (1), p.71

Ort / Verlag

Cambridge: Elsevier Limited

Erscheinungsjahr

2005

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Vγ9Vδ2 T lymphocytes, a major γδ T lymphocyte subset in humans, display cytolytic activity against various tumor cells upon recognition of yet uncharacterized structures. Here, we show that an entity related to the mitochondrial F1-ATPase is expressed on tumor cell surface and promotes tumor recognition by Vγ9Vδ2 T cells. When immobilized, purified F1-ATPase induces selective activation of this lymphocyte subset. The Vγ9Vδ2 T cell receptors (TCR) and the F1-ATPase also bind a delipidated form of apolipoprotein A-I (apo A-I), as demonstrated by surface plasmon resonance. Moreover, the presence of apo A-I in the culture medium is required for optimal activation of Vγ9Vδ2 T cells by tumors expressing F1-ATPase. This study thus describes an unanticipated tumor recognition mechanism by Vγ9Vδ2 lymphocytes and a possible link between γδ T cell immunity and lipid metabolism.