Details

Autor(en) / Beteiligte

• Jittimanee, Suphattra
• Ayudhya, Suparlark Nuntawan Na
• Kedkovid, Roongtham
• Teankum, Komkrich
• Suradhat, Sanipa
• Thanawongnuwech, Roongroje

Titel

Enhancing Specific Antibodies Using a Developed Sub-unit PCV2b Vaccination in a PCV2-affacted Herd

Ist Teil von

• Wētchasān sattawaphāet, 2013-12, Vol.43 (4), p.573

Ort / Verlag

Bangkok: Chulalongkorn University, Faculty of Veterinary Science

Erscheinungsjahr

2013

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Porcine circovirus type 2 (PCV2) causes multisystemic diseases called porcine circovirus associated disease (PCVAD) in pigs leading to a significant economic loss in the swine industry. The objective of this study was to determine the efficacy of a developed sub-unit PCV2b vaccine using a recombinant truncated capsid protein expressed in Escherichia coli in PCVAD-affected pig farms. Five-week-old conventional pigs were allocated into 2 groups: vaccinated and control groups placed in the same building. The vaccinated pigs were given two shots of a developed vaccine with 2-week interval on day 0 and 14. Serum samples were collected from 10 randomly selected pigs of each group. IPMA and in-house indirect ELISA were used to evaluate antibody titers on 0, 14, 28, 77 and 119 days post first vaccination. This study demonstrated that the developed sub-unit PCV2b vaccine had potential for use as a future vaccine candidate. However, more field trials on production parameter and other parameters are needed for vaccine efficacy evaluation.