Details

Autor(en) / Beteiligte

• Fuchs, Sebastian W.
• Grundmann, Florian
• Kurz, Michael
• Kaiser, Marcel
• Bode, Helge B.

Titel

Fabclavines: Bioactive Peptide-Polyketide-Polyamino Hybrids from Xenorhabdus

Ist Teil von

• Chembiochem : a European journal of chemical biology, 2014-03, Vol.15 (4), p.512-516

Ort / Verlag

Weinheim: WILEY-VCH Verlag

Erscheinungsjahr

2014

Quelle

Wiley-Blackwell Journals

Beschreibungen/Notizen

• The structure of the fabclavines—unique mixtures of nonribosomally derived peptide–polyketide hybrids connected to an unusual polyamino moiety—has been solved by detailed NMR and MS methods. These compounds have been identified in two different entomopathogenic Xenorhabdus strains, thereby leading also to the identification of the fabclavine biosynthesis gene cluster. Detailed analysis of these clusters and initial mutagenesis experiments allowed the prediction of a biosynthesis pathway in which the polyamino moiety is derived from an unusual type of fatty acid synthase that is normally involved in formation of polyunsaturated fatty acids. As fabclavines show broad‐spectrum activity against bacteria, fungi, and other eukaryotic cells, they might act as “protection factors” against all kinds of food competitors during the complex life cycle of Xenorhabdus, its nematode host, and their insect prey. A novel tri(hy)brid: The structures and biosynthesis of fabclavines, novel peptide–polyketide–polyamino natural products from entomopathogenic Xenorhabdus, were elucidated. They exhibit broad‐spectrum biological activity and an unusual polyamino moiety derived from polyunsaturated fatty‐acid‐like biosynthesis.