Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
Direct Spectroscopic Detection of the Orientation of Free OH Groups in Methyl Lactate-(Water)1,2 Clusters: Hydration of a Chiral Hydroxy Ester
Ist Teil von
Angewandte Chemie (International ed.), 2014-01, Vol.53 (4), p.1156-1159
Auflage
International ed. in English
Ort / Verlag
Weinheim: WILEY-VCH Verlag
Erscheinungsjahr
2014
Link zum Volltext
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
Hydration of chiral molecules is a subject of significant current interest in light of recent experimental observations of chirality transfer from chiral solutes to water in solution and the important roles which water plays in biological events. Using a broadband chirped pulse and a cavity based microwave spectrometer, we detected spectroscopic signatures of the mono‐ and dihydrates of methyl lactate, a chiral hydroxy ester. Surprisingly, these small hydration clusters show highly specific binding preferences. Not only do they strongly prefer the insertion H‐bonding topology, but they also favor specific pointing direction(s) for their non‐H‐bonded hydroxy group(s). We observed that the particular dihydrate conformer identified is not the most stable one predicted. This work highlights the superior capability of high‐resolution spectroscopy to identify specific water binding topologies, and provides quantitative data to test state‐of‐the‐art theory.
Small hydration clusters of methyl lactate show surprisingly specific binding preferences. They strongly prefer the insertion H‐bonding topology, and favor specific orientation(s) for their non‐H‐bonded hydroxy group(s). Using a broadband chirped pulse and cavity based microwave spectroscopy, direct detection of such unique conformations of the methyl lactate–(water)1,2 clusters is possible.