Details

Autor(en) / Beteiligte

• Kotel’nikova, O. V.
• Alliluev, A. P.
• Drozhzhina, E. Yu
• Koroleva, I. S.
• Sitnikova, E. A.
• Zinchenko, A. A.
• Gordeeva, E. A.
• Melikhova, T. D.
• Nokel, E. A.
• Zhigis, L. S.
• Zueva, V. S.
• Razgulyaeva, O. A.
• Serova, O. V.
• Yagudaeva, E. Yu
• Rumsh, L. D.

Titel

Protective properties of recombinant IgA1 protease from meningococcus

Ist Teil von

• Biochemistry (Moscow). Supplement. Series B, Biomedical chemistry, 2013-10, Vol.7 (4), p.305-310

Ort / Verlag

Boston: Springer US

Erscheinungsjahr

2013

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The study of enzymatic and protective properties of recombinant IgA1 protease in active and mutant form has shown that the active form of IgA1 protease exhibited species- and type-specificity for mouse and human immunoglobulins. A mutant form, lacking enzymatic activity, had protective properties against meningococcal infection, induced by meningococcus serogroup A, B and C; it protected mice from lethal infection by live virulent cultures of heterologous serogroups of meningococcus. The results obtained in this study suggest that IgA1 protease may be considered as a perspective preparation at the stages of development of a polyvalent vaccine for protection of human against meningococcal infections of various etiology.