Chemical and Pharmaceutical Bulletin, 1994/02/15, Vol.42(2), pp.222-227
1994
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Details
- Autor(en) / Beteiligte
- Titel
- Preparation and Reaction of 3-Oxo-3H-pyrazolo[1, 5-a]indole Derivatives
- Ist Teil von
- Chemical and Pharmaceutical Bulletin, 1994/02/15, Vol.42(2), pp.222-227
- Ort / Verlag
- Tokyo: The Pharmaceutical Society of Japan
- Erscheinungsjahr
- 1994
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- An alternative method to prepare 3-oxo-2-phenyl-3H-pyrazolo[1, 5-a]indoles starting from indoline-2-carboxylic acid was explored. The reaction with nucleophilic agents allowed us to introduce the properly substituted alkyl substituents at C-4 of the 4H-pyrazolo[1, 5-a]indoles. The 2, 3-dichloro-5, 6-dicyano-p-benzoquinone (DDQ) oxidation of these products gave the 3-oxo-2-phenyl-3H-pyrazolo[1, 5-a]indole derivatives. Selective Keto-enol tautomerizations of these 1, 5-diketo-monoene system were observed.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0009-2363eISSN: 1347-5223DOI: 10.1248/cpb.42.222Titel-ID: cdi_proquest_journals_1460265722
- Format
- –
- Schlagworte
- 2-pyrazoline-4, 5-dione-5-methide, 3-hydroxy-4H-pyrazolo[1, 5-a]indole, 3-oxo-3H-pyrazolo[1, 5-a]indole, Chemistry, dimeric product, Exact sciences and technology, Heterocyclic compounds, Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings, keto-enol tautomerization, Michael addition, Organic chemistry, Preparations and properties