Details

Autor(en) / Beteiligte

• MIWA, TOSHINOBU
• ICHIKAWA, MASAKI
• TSUNO, MASANORI
• HATTORI, TEIICHI
• MIYAKAWA, TAKESHI
• KAYANO, MASANORI
• MIYAKE, YASUO

Titel

Direct Liquid Chromatographic Resolution of Racemic Compounds. Use of Ovomucoid as a Column Ligand

Ist Teil von

• Chemical and Pharmaceutical Bulletin, 1987/02/25, Vol.35(2), pp.682-686

Ort / Verlag

Tokyo: The Pharmaceutical Society of Japan

Erscheinungsjahr

1987

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• A new chiral recognition column, with conjugated ovomucoid as the ligand, was developed. This column may be employed for the chiral resolution of acids as well as amines without derivatization. The retention time, capacity factor and resolution factor were dependent on pH, buffer strength and 2-propanol concentration of the mobile phase. For chlorpheniramine, a resolution factor of 1.5 was obtained.