Details

Autor(en) / Beteiligte

• KAKEMI, KIICHIRO
• SEZAKI, HITOSHI
• KONDO, TAKASHI

Titel

Absorption and Excretion of Drugs. XLI. Studies on the Gastrointestinal Absorption of 2-Pyridine Aldoxime Methiodide and Its Derivatives

Ist Teil von

• Chemical and Pharmaceutical Bulletin, 1969/09/25, Vol.17(9), pp.1864-1870

Ort / Verlag

Tokyo: The Pharmaceutical Society of Japan

Erscheinungsjahr

1969

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• The gastrointestinal absorption of pyridine aldoxime methiodides has been studied in rats using single loop and perfusion techniques. Contrary to their apparent physicochemical properties, these compounds were absorbed from the intestine to an appreciable extent but not from the stomach and the rectum within one hour. The absorption from the intestine became saturated when the concentration of the drugs increased and one will inhibit the absorption of the other. The presence of a metabolic inhibitor in the drug solution had no effect on the absorption of these compounds. Despite the complexity of the systems used, a straight line relationship between the reciprocal of absorption rate and the reciprocal of initial concentration was obtained for each compound studied.