Details

Autor(en) / Beteiligte

• Li, Guang Zhao
• Chai, Ok Hee
• Lee, Moo Sam
• Han, Eui-Hyeog
• Kim, Hyoung Tae
• Song, Chang Ho

Titel

Inhibitory Effects of Houttuynia cordata Water Extracts on Anaphylactic Reaction and Mast Cell Activation

Ist Teil von

• Biological and Pharmaceutical Bulletin, 2005, Vol.28(10), pp.1864-1868

Ort / Verlag

Japan: The Pharmaceutical Society of Japan

Erscheinungsjahr

2005

Quelle

MEDLINE

Beschreibungen/Notizen

• The present study was investigated the effect of Houttuynia cordata THUNB water extract (HCWE) on mast cell-mediated anaphylactic reactions. The mast cell-mediated anaphylactic reaction is involved in many allergic diseases such as asthma and allergic rhinitis. HCWE has been used as a traditional medicine in Korea and is known to have an antioxidant and anti-cancer activities. However, its specific effect of mast cell-mediated anaphylactic reactions is still unknown. We examined whether HCWE could inhibit compound 48/80-induced systemic anaphylaxis, IgE-mediated passive cutaneous anaphylaxis (PCA), and mast cell activation. The oral administration of HCWE inhibited compound 48/80-induced systemic anaphylaxis in mice. HCWE also inhibited the local allergic reaction, PCA, activated by anti-dinitrophenyl (DNP) IgE antibody in rats. HCWE reduced the compound 48/80-induced mast cell degranulation and colchicine-induced deformation of rat peritoneal mast cells (RPMC). Moreover, HCWE dose-dependently inhibited histamine release and calcium uptake of RPMC induced by compound 48/80 or anti-DNP IgE. HCWE increased the level of intracellular cAMP and inhibited significantly the compound 48/80-induced cAMP reduction in RPMC. These results suggest that HCWE may be beneficial in the treatment of mast cell-mediated anaphylactic responses.