UNIVERSI
TÄ
TS-
BIBLIOTHEK
P
ADERBORN
Anmelden
Menü
Menü
Start
Hilfe
Blog
Weitere Dienste
Neuerwerbungslisten
Fachsystematik Bücher
Erwerbungsvorschlag
Bestellung aus dem Magazin
Fernleihe
Einstellungen
Sprache
Deutsch
Deutsch
Englisch
Farbschema
Hell
Dunkel
Automatisch
Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist
gegebenenfalls
nur via VPN oder Shibboleth (DFN-AAI) möglich.
mehr Informationen...
Universitätsbibliothek
Katalog
Suche
Details
Zur Ergebnisliste
Ergebnis 9 von 12
Datensatz exportieren als...
BibTeX
A polymorphism in the TYMP gene is associated with the outcome of HLA‐identical sibling allogeneic stem cell transplantation
American journal of hematology, 2013-10, Vol.88 (10), p.883-889
Guillem, Vicent
Hernández‐Boluda, Juan Carlos
Gallardo, David
Buño, Ismael
Bosch, Anna
Martínez‐Laperche, Carolina
Cámara, Rafael
Brunet, Salut
Martin, Carmen
Nieto, José B.
Martínez, Carmen
Pérez, Ariadna
Montoro, Juan
Garcia‐Noblejas, Ana
Solano, Carlos
2013
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Guillem, Vicent
Hernández‐Boluda, Juan Carlos
Gallardo, David
Buño, Ismael
Bosch, Anna
Martínez‐Laperche, Carolina
Cámara, Rafael
Brunet, Salut
Martin, Carmen
Nieto, José B.
Martínez, Carmen
Pérez, Ariadna
Montoro, Juan
Garcia‐Noblejas, Ana
Solano, Carlos
Titel
A polymorphism in the TYMP gene is associated with the outcome of HLA‐identical sibling allogeneic stem cell transplantation
Ist Teil von
American journal of hematology, 2013-10, Vol.88 (10), p.883-889
Ort / Verlag
United States: Wiley Subscription Services, Inc
Erscheinungsjahr
2013
Quelle
Wiley-Blackwell Full Collection
Beschreibungen/Notizen
Thymidine phosphorylase (TYMP), an enzyme involved in nucleotide synthesis, has been implicated in critical biological processes such as DNA replication, protection against mutations, and tissue repair. In this work, we retrospectively evaluated the influence of a polymorphism in the TYMP gene (rs112723255; G/A) upon the outcome of 448 patients subjected to allogeneic stem cell transplantation (allo‐SCT) from an human leukocyte antigen (HLA)‐identical sibling donor. The TYMP genotype of patients correlated with overall survival—carriers of the minor allele (A) being at an increased risk of dying after transplantation (hazard ratio, HR = 1.9; P = 0.004). This effect was mostly due to differences in transplant toxicity‐related mortality (HR = 2.5; P = 0.029). In addition, the TYMP genotype of donors was associated with the risk of chronic graft‐versus‐host disease (GVHD)—carriers of the minor allele being at an increased risk of developing this complication ([HR] = 1.7; P = 0.039). The impact of such polymorphism on the risk of chronic GVHD is limited to patients transplanted in early stage disease (HR = 2.2; P = 0.019). The combination of a donor harboring the minor allele with a patient homozygous for the major allele was associated with the highest risk of chronic GVHD (HR = 2.8; P = 0.008). These findings provide the first evidence of the significant impact of the TYMP genotype upon the clinical outcome of patients treated with HLA‐identical sibling allo‐SCT. Am. J. Hematol. 88:883–889, 2013. © 2013 Wiley Periodicals, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0361-8609
eISSN: 1096-8652
DOI: 10.1002/ajh.23523
Titel-ID: cdi_proquest_journals_1437148463
Format
–
Schlagworte
Adolescent
,
Adult
,
Aged
,
Alleles
,
Child
,
Child, Preschool
,
Chronic Disease
,
Female
,
Genotype
,
Graft vs Host Disease - etiology
,
Graft vs Host Disease - genetics
,
Graft vs Host Disease - mortality
,
Hematologic Neoplasms - genetics
,
Hematologic Neoplasms - mortality
,
Hematologic Neoplasms - therapy
,
Hematology
,
Histocompatibility Testing
,
Humans
,
Infant
,
Male
,
Middle Aged
,
Polymorphism, Genetic
,
Retrospective Studies
,
Risk Factors
,
Siblings
,
Stem Cell Transplantation
,
Survival Rate
,
Thymidine Phosphorylase - genetics
,
Time Factors
,
Transplantation, Homologous
Weiterführende Literatur
Empfehlungen zum selben Thema automatisch vorgeschlagen von
bX