Proceedings of the National Academy of Sciences - PNAS, 2013-09, Vol.110 (37), p.15043-15048
2013
Details
- Autor(en) / Beteiligte
- Titel
- Insulin growth factor signaling is regulated by microRNA-486, an underexpressed microRNA in lung cancer
- Ist Teil von
- Proceedings of the National Academy of Sciences - PNAS, 2013-09, Vol.110 (37), p.15043-15048
- Ort / Verlag
- United States: National Academy of Sciences
- Erscheinungsjahr
- 2013
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- MicroRNAs (miRNAs) are small 19- to 24-nt noncoding RNAs that have the capacity to regulate fundamental biological processes essential for cancer initiation and progression. In cancer, miRNAs may function as oncogenes or tumor suppressors. Here, we conducted global profiling for miRNAs in a cohort of stage 1 nonsmall cell lung cancers (n = 81) and determined that miR-486 was the most down-regulated miRNA in tumors compared with adjacent uninvolved lung tissues, suggesting that miR-486 loss may be important in lung cancer development. We report that miR-486 directly targets components of insulin growth factor (IGF) signaling including insulin-like growth factor 1 (IGF1), IGF1 receptor (IGF1R), and phosphoinositide-3-kinase, regulatory subunit 1 (alpha) (PIK3R1, or p85a) and functions as a potent tumor suppressor of lung cancer both in vitro and in vivo. Our findings support the role for miR-486 loss in lung cancer and suggest a potential biological link to p53.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0027-8424eISSN: 1091-6490DOI: 10.1073/pnas.1307107110Titel-ID: cdi_proquest_journals_1432867663
- Format
- –
- Schlagworte
- 3' Untranslated Regions, Animals, Apoptosis, Biological Sciences, Cancer, Carcinoma, Non-Small-Cell Lung - genetics, Carcinoma, Non-Small-Cell Lung - metabolism, Carcinoma, Non-Small-Cell Lung - pathology, Cell cycle, Cell Cycle Checkpoints, Cell Line, Tumor, Cell lines, Cell Movement, Cell Proliferation, Class Ia Phosphatidylinositol 3-Kinase - antagonists & inhibitors, Class Ia Phosphatidylinositol 3-Kinase - genetics, Class Ia Phosphatidylinositol 3-Kinase - metabolism, Delta cells, Gene Expression Regulation, Neoplastic, Genes, p53, Genes, Tumor Suppressor, Humans, Insulin-Like Growth Factor I - antagonists & inhibitors, Insulin-Like Growth Factor I - genetics, Insulin-Like Growth Factor I - metabolism, Insulin-like growth factors, Lung cancer, Lung neoplasms, Lung Neoplasms - genetics, Lung Neoplasms - metabolism, Lung Neoplasms - pathology, Lungs, Mice, Mice, Nude, MicroRNA, MicroRNAs - genetics, MicroRNAs - metabolism, Receptor, IGF Type 1 - antagonists & inhibitors, Receptor, IGF Type 1 - genetics, Receptor, IGF Type 1 - metabolism, Ribonucleic acid, RNA, RNA, Small Interfering - genetics, Signal Transduction, Small interfering RNA, Tissues, Tumors