Details

Autor(en) / Beteiligte

• Golbabaei, Sanaz
• Bazl, Roya
• Golestanian, Sahand
• Nabati, Farzaneh
• Omrany, Zinat Bahrampour
• Yousefi, Behnam
• Hajiaghaee, Reza
• Rezazadeh, Shamsali
• Amanlou, Massoud

Titel

Urease inhibitory activities of [Beta]-boswellic acid derivatives

Ist Teil von

• Daru, 2013-01, Vol.21 (1), p.1

Ort / Verlag

New York: Springer Nature B.V

Erscheinungsjahr

2013

Quelle

Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals

Beschreibungen/Notizen

• Boswellia carterii have been used in traditional medicine for many years for the management of different gastrointestinal disorders. Four pentacyclic triterpenoid acids were isolated from Boswellia carterii and identified by NMR and mass spectroscopic analysis (compounds 1, 3-O-acetyl-9,11-dehydro-β-boswellic acid; 2, 3-O-acetyl-11-hydroxy-β-boswellic acid; 3. 3-O-acetyl-11-keto-β-boswellic acid and 4, 11-keto-β-boswellic acid). Their inhibitory activity on Jack bean urease was evaluated. Docking and pharmacophore analysis using AutoDock 4.2 and Ligandscout 3.03 programs were also performed to explain possible mechanism of interaction between the isolated compounds and urease enzyme. It was found that compound 1 has the strongest inhibitory activity against Jack bean urease (IC^sub 50^ = 6.27 ± 0.03 uM), compared with thiourea as a standard inhibitor (IC^sub 50^ = 21.1 ± 0.3 uM). The inhibition potency is probably due to the formation of appropriate hydrogen bonds and hydrophobic interactions between the investigated compounds and urease enzyme active site and confirms its traditional usage.