Details

Autor(en) / Beteiligte

• Thomas, Kim S
• Crook, Angela M
• Nunn, Andrew J
• Foster, Katharine A
• Mason, James M
• Chalmers, Joanne R
• Nasr, Ibrahim S
• Brindle, Richard J
• English, John
• Meredith, Sarah K
• Reynolds, Nicholas J
• de Berker, David
• Mortimer, Peter S
• Williams, Hywel C

Titel

Penicillin to Prevent Recurrent Leg Cellulitis

Ist Teil von

• The New England journal of medicine, 2013-05, Vol.368 (18), p.1695-1703

Ort / Verlag

Waltham, MA: Massachusetts Medical Society

Erscheinungsjahr

2013

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Recurrence of leg cellulitis is common. In this pragmatic community study involving 274 patients in the United Kingdom and Ireland, daily low-dose penicillin prophylaxis decreased recurrent cellulitis during the active-treatment stage but not subsequently. Cellulitis of the leg is a common infection of the skin and subcutaneous tissue. 1 , 2 Most infections that affect intact skin are thought to be due to streptococci, 3 , 4 although other organisms may be responsible if the integrity of the skin is compromised. Each recurrent episode of cellulitis results in further damage to the lymphatic system 5 , 6 and is associated with additional morbidity and health care costs. 7 Current guidelines for the prevention of cellulitis are consensus-based and recommend prophylactic antibiotic therapy for recurrent disease. 8 , 9 Three small, randomized, controlled trials have suggested a possible benefit of prophylactic antibiotics in patients . . .