Nature neuroscience, 2013-05, Vol.16 (5), p.526-528
2013
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Taste-independent nutrient selection is mediated by a brain-specific Na+ /solute co-transporter in Drosophila
- Ist Teil von
- Nature neuroscience, 2013-05, Vol.16 (5), p.526-528
- Ort / Verlag
- United States: Nature Publishing Group
- Erscheinungsjahr
- 2013
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Animals can determine the nutritional value of sugar without the influence of taste. We examined a Drosophila mutant that is insensitive to the nutritional value of sugars, responding only to the concentration (that is, sweetness). The affected gene encodes a sodium/solute co-transporter-like protein, designated SLC5A11 (or cupcake), which is structurally similar to mammalian sodium/glucose co-transporters that transport sugar across the intestinal and renal lumen. However, SLC5A11 was prominently expressed in 10-13 pairs of R4 neurons of the ellipsoid body in the brain and functioned in these neurons for selecting appropriate foods.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1097-6256eISSN: 1546-1726DOI: 10.1038/nn.3372Titel-ID: cdi_proquest_journals_1346862902
- Format
- –
- Schlagworte
- Analysis of Variance, Animals, Animals, Genetically Modified, Base Sequence, Brain, Brain - cytology, Brain - metabolism, CD8 Antigens - genetics, Choice Behavior - physiology, Dose-Response Relationship, Drug, Drosophila - physiology, Drosophila Proteins - genetics, Drosophila Proteins - metabolism, Food, Food Deprivation - physiology, Food Preferences - physiology, Gene Expression Regulation - drug effects, Gene Expression Regulation - genetics, Glucose, Glucose - administration & dosage, Glycogen - metabolism, Green Fluorescent Proteins - genetics, Hemolymph - metabolism, Humans, Insects, Mutation, Mutation - genetics, Neurons - metabolism, Neurosciences, Receptors, Cell Surface - genetics, RNA Interference, Sodium, Sodium-Glucose Transport Proteins - genetics, Sodium-Glucose Transport Proteins - metabolism, Taste - genetics, Transcription Factors - genetics