Details

Autor(en) / Beteiligte

• Pelletier, Caroline C
• Koppe, Laetitia
• Croze, Marine L
• Kalbacher, Emilie
• Vella, Roxane E
• Guebre-egziabher, Fitsum
• Géloën, Alain
• Badet, Lionel
• Fouque, Denis
• Soulage, Christophe O

Titel

White adipose tissue overproduces the lipid-mobilizing factor zinc [alpha]2-glycoprotein in chronic kidney disease

Ist Teil von

• Kidney international, 2013-05, Vol.83 (5), p.878

Ort / Verlag

London: Elsevier Limited

Erscheinungsjahr

2013

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Chronic kidney disease (CKD) is frequently associated with protein-energy wasting, a recognized strong predictive factor of mortality. Zinc α2-glycoprotein (ZAG) is a new adipokine involved in body weight control through its lipid-mobilizing activity. Here we tested whether the uremic environment in CKD could alter ZAG production by white adipose tissue and contribute to CKD-associated metabolic disturbances. Compared with normal plasma, uremic plasma induced a significant increase in ZAG synthesis (124%), was associated with a significant increase in basal lipolysis (31%), and significantly blunted lipogenesis (-53%) in 3T3-L1 adipocytes in vitro. In 5/6 nephrectomized rats and mice in vivo, there was a significant decrease in white adipose tissue accretion (-44% and -43%, respectively) and a significantly higher white adipose tissue content of ZAG protein than in sham-operated, pair-fed control animals (498% and 106%, respectively). Subcutaneous white adipose tissue biopsies from patients with end-stage renal disease exhibited a higher content of ZAG (573%) than age-matched controls. Thus, the ZAG content is increased in white adipose tissue from patients or animal models with CKD. Overproduction of ZAG in CKD could be a major contributor to metabolic disturbances associated with CKD.