Details

Autor(en) / Beteiligte

• Smith, Erin N
• Koller, Daniel L
• Panganiban, Corrie
• Szelinger, Szabolcs
• Zhang, Peng
• Badner, Judith A
• Barrett, Thomas B
• Berrettini, Wade H
• Bloss, Cinnamon S
• Byerley, William
• Coryell, William
• Edenberg, Howard J
• oud, Tatiana
• Gershon, Elliot S
• Greenwood, Tiffany A
• Guo, Yiran
• Hipolito, Maria
• Keating, Brendan J
• Lawson, William B
• Liu, Chunyu
• Mahon, Pamela B
• McInnis, Melvin G
• McMahon, Francis J
• McKinney, Rebecca
• Murray, Sarah S
• Nievergelt, Caroline M
• Jr, John INurnberger
• Nwulia, Evaristus A
• Potash, James B
• Rice, John
• Schulze, Thomas G
• Scheftner, William A
• Shilling, Paul D
• Zandi, Peter P
• Zöllner, Sebastian
• Craig, David W
• Schork, Nicholas J
• Kelsoe, John R

Titel

Genome-Wide Association of Bipolar Disorder Suggests an Enrichment of Replicable Associations in Regions near Genes: e1002134

Ist Teil von

• PLoS genetics, 2011-06, Vol.7 (6)

Ort / Verlag

San Francisco: Public Library of Science

Erscheinungsjahr

2011

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Although a highly heritable and disabling disease, bipolar disorder's (BD) genetic variants have been challenging to identify. We present new genotype data for 1,190 cases and 401 controls and perform a genome-wide association study including additional samples for a total of 2,191 cases and 1,434 controls. We do not detect genome-wide significant associations for individual loci; however, across all SNPs, we show an association between the power to detect effects calculated from a previous genome-wide association study and evidence for replication (P = 1.5×10-7). To demonstrate that this result is not likely to be a false positive, we analyze replication rates in a large meta-analysis of height and show that, in a large enough study, associations replicate as a function of power, approaching a linear relationship. Within BD, SNPs near exons exhibit a greater probability of replication, supporting an enrichment of reproducible associations near functional regions of genes. These results indicate that there is likely common genetic variation associated with BD near exons (±10 kb) that could be identified in larger studies and, further, provide a framework for assessing the potential for replication when combining results from multiple studies.