Details

Autor(en) / Beteiligte

• Gerson, Donald E.
• Szabó, George

Titel

The effects of single gene substitution on the mammalian melanocyte system-a qualitative and quantitative histological study in the C57BL and DBL mice

Ist Teil von

• American journal of physical anthropology, 1969-11, Vol.31 (3), p.363-381

Ort / Verlag

New York: Wiley Subscription Services, Inc., A Wiley Company

Erscheinungsjahr

1969

Quelle

Wiley Online Library

Beschreibungen/Notizen

• About 160 skin samples from the tail, sole, palm, ear and scrotum of DBL and C57BL/St mice were “split” with NaBr and treated with DOPA. A quantitative and qualitative microscopic analysis showed that: (a) the two strains did not differ consistently in the frequency of epidermal or dermal melanocytes; nor did the sexes differ from each other in this respect; (b) the melanocytes of the two strains differed morphologically. The DBL melanocytes were generally larger, with melanin‐congested perikarya. They had fewer dendrites than the C57BL melanocytes and their dendrites were shorter; and (c) the melanocytes of the DBL and C57BL strains differed in activity, the DBL melanocytes donating less melanin to Malpighian cells than did the C57BL melanocytes. It was concluded that the morphology of DBL and C57BL melanocytes is largely autonomously determined, although regional differences in melanocyte morphology suggest that the cellular environment also plays some part in influencing melanoblast differentiation.