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Positive C1q staining associated with poor renal outcome in membranoproliferative glomerulonephritis
Ist Teil von
Clinical and experimental nephrology, 2013-02, Vol.17 (1), p.92-98
Ort / Verlag
Japan: Springer Japan
Erscheinungsjahr
2013
Quelle
SpringerLink
Beschreibungen/Notizen
Background
Pathogenesis and clinical prognosis of membranoproliferative glomerulonephritis (MPGN) has not yet been established.
Methods
We conducted a retrospective study of 41 patients with MPGN (type I and III) and examined the renal survival. In addition, factors contributing to survival time were analyzed.
Results
Fourteen patients (34 %) were classified into the renal death group. Patients with nephrotic syndrome and positive C1q staining of glomerular deposits showed a particularly poor prognosis. Significantly higher frequency of nephrotic syndrome and higher urinary protein excretion were observed in the renal death group (
p
= 0.0002,
p
= 0.0002) than in the renal survival group. The intensity of C1q staining was positively correlated with the severity of the proteinuria (
p
= 0.004). Factors that influenced the survival time were positive C1q staining of glomerular deposits (
p
= 0.003), presence of nephrotic syndrome (
p
= 0.004), serum albumin (
p
= 0.02), and proteinuria (
p
= 0.04).
Conclusions
C1q staining in glomerular deposits and nephrotic syndrome were important factors influencing the prognosis and outcome in MPGN patients. C1q deposition may play a key role in the pathogenesis of MPGN, as evidenced by numerous observations, such as induction of proteinuria.