Hepatology (Baltimore, Md.), 2012-12, Vol.56 (6), p.2336-2343
2012
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- Autor(en) / Beteiligte
- Titel
- Promotion of liver regeneration/repair by farnesoid X receptor in both liver and intestine in mice
- Ist Teil von
- Hepatology (Baltimore, Md.), 2012-12, Vol.56 (6), p.2336-2343
- Ort / Verlag
- Hoboken: Wiley Subscription Services, Inc., A Wiley Company
- Erscheinungsjahr
- 2012
- Quelle
- Wiley-Blackwell Journals
- Beschreibungen/Notizen
- Farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily and is the primary bile acid receptor. We previously showed that FXR was required for the promotion of liver regeneration/repair after physical resection or liver injury. However, the mechanism by which FXR promotes liver regeneration/repair is still unclear. Here we show that both hepatic‐FXR and intestine‐FXR contributed to promote liver regeneration/repair after either 70% partial hepatectomy or carbon tetrachloride‐induced liver injury. Hepatic FXR, but not intestine FXR, is required for the induction of Foxm1b gene expression in liver during liver regeneration/repair. In contrast, intestine FXR is activated to induce FGF15 expression in intestine after liver damage. Ectopic expression of FGF15 was able to rescue the defective liver regeneration/repair in intestine‐specific FXR null mice. Conclusion: These results demonstrate that, in addition to the cell‐autonomous effect of hepatic FXR, the endocrine FGF15 pathway activated by FXR in intestine also participates in the promotion of liver regeneration/repair. (HEPATOLOGY 2012;56:2336–2343)
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0270-9139eISSN: 1527-3350DOI: 10.1002/hep.25905Titel-ID: cdi_proquest_journals_1221565469
- Format
- –
- Schlagworte
- Analysis of Variance, Animals, Bile, Bile Acids and Salts - metabolism, Biological and medical sciences, Carbon Tetrachloride - toxicity, Chemical and Drug Induced Liver Injury - metabolism, Chemical and Drug Induced Liver Injury - pathology, Chemical and Drug Induced Liver Injury - surgery, Cholesterol 7-alpha-Hydroxylase - genetics, Cholesterol 7-alpha-Hydroxylase - metabolism, Fibroblast Growth Factors - genetics, Fibroblast Growth Factors - metabolism, Gastroenterology. Liver. Pancreas. Abdomen, Gene Expression Regulation, Hepatectomy, Hepatology, Intestines - metabolism, Liver, Liver - metabolism, Liver Regeneration - genetics, Liver. Biliary tract. Portal circulation. Exocrine pancreas, Male, Medical sciences, Mice, Mice, Knockout, Necrosis, Receptors, Cytoplasmic and Nuclear - genetics, Receptors, Cytoplasmic and Nuclear - metabolism, RNA, Messenger - metabolism, Rodents