Details

Autor(en) / Beteiligte

• Cardinale, Jens
• Ermert, Johannes
• Kügler, Fabian
• Helfer, Andreas
• Brandt, Marie R.
• Coenen, Heinz H.

Titel

Carrier-effect on palladium-catalyzed, nucleophilic 18F-fluorination of aryl triflates

Ist Teil von

• Journal of labelled compounds & radiopharmaceuticals, 2012-10, Vol.55 (12), p.450-453

Ort / Verlag

Chichester: Blackwell Publishing Ltd

Erscheinungsjahr

2012

Link zum Volltext

Quelle

Wiley Online Library Journals

Beschreibungen/Notizen

• A recently published palladium‐catalyzed preparation of fluoroarenes starting from caesium fluoride attracted interest as a new alternative for radiofluorination. To test this method, a suitable protocol for the synthesis of 4‐[18F]fluorotoluene and 1‐[18F]fluoronaphthalene as model systems has been developed. The possibility to perform the reaction under no‐carrier‐added condition was of special interest. It was found out, however, that the reaction requires the presence of carrier, thus limiting the method to syntheses of radiotracers with low specific activity. Copyright © 2012 John Wiley & Sons, Ltd. The new palladium‐catalyzed, nucleophilic fluorination of non‐activated aryl triflates was transferred to radiofluorination. The dependence on the amount of fluoride showed that the method is not suitable for production of [18F]fluoroarenes of high specific activity.