Nutrition (Burbank, Los Angeles County, Calif.), 2006-03, Vol.22 (3), p.327-331
2006
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Details
- Autor(en) / Beteiligte
- Titel
- Preconceptional fasting of fathers alters serum glucose in offspring of mice
- Ist Teil von
- Nutrition (Burbank, Los Angeles County, Calif.), 2006-03, Vol.22 (3), p.327-331
- Ort / Verlag
- New York, NY: Elsevier Inc
- Erscheinungsjahr
- 2006
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Maternal nutrition has long-term effects on offspring characteristics. Similar effects mediated through fathers have not been tested. Outbred Swiss male mice were fasted one or six times 1 to 4 wk before mating. Offspring were killed at age intervals of 4 to 10 wk and their sera were analyzed for glucose, corticosterone, and insulin-like growth factor-1. Statistical linear mixed effects models were used to determine treatment (paternal diet restriction versus control) differences and possible effects of covariates, including sex, litter membership, and litter size. Paternal food deprivation resulted in a consistent decrease in average serum glucose in male and female offspring. Significant changes in corticosterone and insulin-like growth factor-1 were found for some groups. The results indicated a male-mediated transgenerational effect on metabolism- and growth-related parameters, in particular glucose. Effects of paternal nutritional experiences on offspring metabolism, if confirmed, would be novel and could have far-reaching implications in the context of transgenerational effects on chronic diseases.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0899-9007eISSN: 1873-1244DOI: 10.1016/j.nut.2005.09.006Titel-ID: cdi_proquest_journals_1139001518
- Format
- –
- Schlagworte
- Age, Animals, Animals, Newborn - blood, Animals, Newborn - metabolism, Biological and medical sciences, blood glucose, Blood Glucose - analysis, Blood Glucose - metabolism, Corticosterone, Corticosterone - blood, Corticosterone - metabolism, Diabetes, Dietary restrictions, Experiments, Fasting, Fasting - physiology, Fathers, Feeding. Feeding behavior, Female, Females, Food, Fundamental and applied biological sciences. Psychology, Glucose, insulin-like growth factor I, Insulin-Like Growth Factor I - metabolism, Insulin-like growth factor-1, Insulin-like growth factors, Linear Models, Litter Size, long term effects, Male, Males, Metabolism, Mice, Models, Animal, Mortality, Nutrition research, Offspring, paternal effect, Paternal fasting, Pregnancy, progeny, Rodents, sexual development, Studies, transgenerational effects, Vertebrates: anatomy and physiology, studies on body, several organs or systems