Details

Autor(en) / Beteiligte

• Ribichini, F.
• Ferrero, V.
• Feola, M.
• Vado, A.
• Antonini-Canterin, F.
• Uslenghi, E.

Titel

C001: I/D polymorphism of the ace gene as a marker of different cardiovascular diseases. Relations with hypertension, coronary atherosclerosis and restenosis after coronary stent implantion

Ist Teil von

• American journal of hypertension, 2000-04, Vol.13 (S2), p.68A-68A

Ort / Verlag

Oxford: Oxford University Press

Erscheinungsjahr

2000

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• The I/D polymorphism of the ACE gene exerts a codominat effect on the plasma ACE level. Diseases known or suspected to be affected by elevated ACE activity would be more likely in patients (pts) with the D allele of the ACE gene. However, the increased ACE activity has never been demonstrated to be a cardiovascular risk factor despite the multiple interactions of ACE with hypertension and atherosclerosis. The role of the I/D polymorphism and ACE plasma activity in hypertension, coronary artery disease (CAD) and restenosis after coronary stenting was evaluated in a consecutive series pts of coronary interventions. Plasma ACE level was measured at admission and quantitative coronary analysis of the coronary arteries was performed before and after the stenting procedure, and at six-month angiography. A total of 730 pts were studied, 333 hypertensive (47%), their ACE level compared to non-hypertensive pts was: 21 ± 15 vs 17 ± 15 U/l (p = 0.014). ACE in 455 pts with single vessel CAD was 19 ± 15 vs 18 ± 15 in 275 pts with multivessel CAD (p = 0.17), and in 158 restenotic pts was 23 ± 20 vs 18 ± 13 in 572 non-restenotic pts (p = 0.0001). I/D distribution in the table: DD ID II χ2 test Hypertensive 128 (38%) 153 (46%) 52 (16%) χ2 = 0.56 Non hypertensive 143 (36%) 193 (49%) 61 (15%) p = 0.75 Single-vessel CAD 168 (37%) 211 (47%) 71 (16%) χ2 = 0.14 Multivessel CAD 103 (37%) 135 (48%) 42 (15%) p = 0.95 Restenosis 72 (46%) 63 (40%) 23 (14%) χ2 = 6.39 Non restenosis 199 (35%) 283 (50%) 90 (15%) p = 0.041 Plasma ACE level is higher in hypertensive pts with CAD, but is not correlated to the degree of CAD. Neointimal growth that after injury caused by coronary stenting, depends on plasma ACE activity; and the I/D polymoprhism of the ACE gene is an indirect marker of this process.