Details

Autor(en) / Beteiligte

• Lim, Michael
• Guccione, Samira
• Haddix, Terri
• Sims, Leroy
• Cheshier, Samuel
• Chu, Pauline
• Vogel, Hannes
• Harsh, Griffith

Titel

[alpha] v [beta] 3 Integrin in central nervous system tumors

Ist Teil von

• Human pathology, 2005-06, Vol.36 (6), p.665

Ort / Verlag

Philadelphia: Elsevier Limited

Erscheinungsjahr

2005

Quelle

Access via ScienceDirect (Elsevier)

Beschreibungen/Notizen

• α vβ 3 is an integrin specifically expressed in endothelial cells of newly forming blood vessels. Integrin-mediated angiogenesis is hypothesized to play a central role in the development and the progression of central nervous system neoplasms. Accordingly, it is considered a potential target for antiangiogenic therapy. In the current study, we compare the expression of α vβ 3 in ependymomas, oligodendrogliomas, pilocytic astrocytomas, medulloblastomas, and vestibular schwannomas (acoustic neuromas). Samples of 5 tumors of each of the 5 tumor types were harvested surgically and frozen. After the pathological diagnosis was confirmed, immunohistochemistry was performed using an anti- α vβ 3 monoclonal antibody (LM609). The expression of α vβ 3 was assessed using a 4-tiered (0-3) grading scheme reflecting the percentage of positively staining vessels. All vestibular schwannomas demonstrated strong (grade 3) α vβ 3 expression. The expression was uniformly prominent in Antoni B regions of the tumors. Of 5 ependymomas, 4 demonstrated uniformly strong α vβ 3 expression. Oligodendrogliomas, medulloblastomas, and pilocytic astrocytomas demonstrated more variable α vβ 3 expression. α vβ 3 may contribute significantly to angiogenesis in vestibular schwannomas and ependymomas. Despite the high vascular density of oligodendrogliomas, pilocytic astrocytomas, and medulloblastomas, these tumors had variable moderate α vβ 3 expression. This discrepancy suggests temporal and/or regional variability in the angiogenesis in these types of tumor. This study provides the first demonstration of α vβ 3 expression in vestibular schwannomas, medulloblastomas, and pilocytic astrocytomas.