Details

Autor(en) / Beteiligte

• Fang, Wen-Liang
• Chang, Shih-Ching
• Lan, Yuan-Tzu
• Huang, Kuo-Hung
• Chen, Jen-Hao
• Lo, Su-Shun
• Hsieh, Mao-Chih
• Li, Anna Fen-Yau
• Wu, Chew-Wun
• Chiou, Shih-Hwa

Titel

Microsatellite Instability Is Associated With a Better Prognosis for Gastric Cancer Patients After Curative Surgery

Ist Teil von

• World journal of surgery, 2012-09, Vol.36 (9), p.2131-2138

Ort / Verlag

New York: Springer-Verlag

Erscheinungsjahr

2012

Quelle

MEDLINE

Beschreibungen/Notizen

• Background Microsatellite instability (MSI) is one of the leading mechanisms for the carcinogenesis of gastric cancer. Its prognostic value is controversial. Methods Between May 1988 and Oct 2003, a total of 214 gastric cancer patients undergoing curative surgery were enrolled, and their MSI statuses were classified as MSI-H (high) or MSI-L/S (low/stable). The clinicopathologic characteristics of MSI-H and MSI-L/S gastric cancers were compared. Results The MSI-H tumors accounted for 11.7 % ( n  = 25) of the 214 total gastric cancers. Although not statistically significant, the MSI-H gastric cancers were more frequently located in the lower third of the stomach (64 % vs. 49.2 %) and were more often the intestinal type (72 % vs. 61.4 %) compared to the MSI-L/S gastric cancers. The MSI-H gastric cancers had a significantly better 5-year overall survival (OS) rate (68 % vs. 47.6 %, p  = 0.030) and a trend of a better 3-year disease-free survival rate (71.8 % vs. 55.2 %, p  = 0.076) compared to the MSI-L/S gastric cancers. A multivariate analysis revealed that pathologic TNM stage and MSI status were the independent prognostic factors for OS after curative surgery. Conclusions Compared to MSI-L/S tumors, MSI-H tumors are associated with a better OS rate for gastric cancer patients after R0 resection.