Details

Autor(en) / Beteiligte

• Cortés, Isabel
• Sánchez-Ruíz, Jesús
• Zuluaga, Susana
• Calvanese, Vincenzo
• Marqués, Miriam
• Hernández, Carmen
• Rivera, Teresa
• Kremer, Leonor
• González-García, Ana
• Carrera, Ana C

Titel

p85[Beta] phosphoinositide 3-kinase subunit regulates tumor progression

Ist Teil von

• Proceedings of the National Academy of Sciences - PNAS, 2012-07, Vol.109 (28), p.11318

Ort / Verlag

Washington: National Academy of Sciences

Erscheinungsjahr

2012

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• PIK3R2 encodes a ubiquitous regulatory subunit (p85β) of PI3K, an enzyme that generates 3-polyphosphoinositides at the plasma membrane. PI3K activation triggers cell survival and migration. We found that p85β expression is elevated in breast and colon carcinomas and that its increased expression correlates with PI3K pathway activation and tumor progression. p85β expression induced moderate PIP3 generation at the cell membrane and enhanced cell invasion. In accordance, genetic alteration of pik3r2 expression levels modulated tumor progression in vivo. Increased p85β expression thus represents a cellular strategy in cancer progression. [PUBLICATION ABSTRACT]