Details

Autor(en) / Beteiligte

• James, Nicholas D
• Hussain, Syed A
• Hall, Emma
• Jenkins, Peter
• Tremlett, Jean
• Rawlings, Christine
• Crundwell, Malcolm
• Sizer, Bruce
• Sreenivasan, Thiagarajan
• Hendron, Carey
• Lewis, Rebecca
• Waters, Rachel
• Huddart, Robert A

Titel

Radiotherapy with or without Chemotherapy in Muscle-Invasive Bladder Cancer

Ist Teil von

• The New England journal of medicine, 2012-04, Vol.366 (16), p.1477-1488

Ort / Verlag

Waltham, MA: Massachusetts Medical Society

Erscheinungsjahr

2012

Quelle

MEDLINE

Beschreibungen/Notizen

• Management of muscle-invasive bladder cancer with radiation is associated with a 45% local relapse rate at 2 years. Concurrent treatment with mitomycin C and fluorouracil reduced recurrence to 33% and was not associated with increased late treatment-related toxicity. Bladder cancer, with more than 385,000 new cases worldwide in 2008, 1 is a major cause of cancer complications. The median age at diagnosis is over 70 years, and since the tumor often is related to smoking, many patients have a substantial number of coexisting illnesses that pose risks for radical surgical approaches. Survival rates are poor for muscle-invasive bladder cancer, with around 45% of patients surviving for 5 years regardless of the type of treatment. 2 – 4 Although surgery is considered the standard therapy, considerable interest in bladder preservation has led to the use of radiotherapy as an alternative, particularly in . . .