Details

Autor(en) / Beteiligte

• Hawryluk, Natalie A
• Scandale, Ivan
• Pollastri, Michael P
• Swinney, David C
• Mannhold, Raimund
• Holenz, Jörg
• Swinney, David
• Pollastri, Michael
• Buschmann, Helmut

Titel

Onchocerciasis Drug Discovery

Ist Teil von

• Neglected Tropical Diseases, 2019, p.161-186

Ort / Verlag

Germany: John Wiley & Sons, Incorporated

Erscheinungsjahr

2019

Quelle

Wiley Online Library All Obooks

Beschreibungen/Notizen

• The current strategies for elimination of onchocerciasis are ineffective against the macrofilaria, or adult worms, and require repeated and prolonged treatments. A novel macrofilaricide is imperative to achieve eradication of this disease and address the potential threat of emerging resistance. Future therapies for targeting onchocerciasis focus on a macrofilaricidal regimen that increases the rate of elimination and is safe to use in co‐endemic regions of Onchocerca volvulus and Loa loa.