Details

Autor(en) / Beteiligte

• Cox, Jr. , Charles S
• Cox, Jr., Charles S.

Titel

Soluble Factors and Mechanisms of Action of Mesenchymal Stem Cells in Traumatic Brain Injury and Organ Injury Induced by Trauma

Ist Teil von

• Cellular Therapy for Neurological Injury, 2016, Vol.1, p.248-269

Ort / Verlag

United Kingdom: CRC Press

Erscheinungsjahr

2016

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Trauma is the leading cause of death worldwide in all individuals between the ages of 1 and 44, and traumatic brain injury (TBI) is the leading cause of death in pediatric populations. There are currently few if any effective therapies to treat the acute edema and increased intracranial pressures (ICPs) resulting from TBI (Chesnut, 2004; Bazarian et al., 2005; Menon, 2009; Shlosberg et al., 2010). Patients who survive the 8.1 Background on Traumatic Brain Injury and Mesenchymal Stem Cells ... 231 8.2 Therapeutic Potential of MSCs ... 232 8.3 Mechanism of Action of MSCs and Soluble Factors in Traumatic Brain Injury ... 233 8.4 Mechanisms of Action of MSCs and Soluble Factors in Organ (Lung and Renal) Injury ... 236 8.4.1 Immunomodulatory Effects of MSCs Mediated via Secreted Soluble Factors ... 237 8.4.2 Antibacterial Peptides and Factors Secreted by MSCs ... 238 8.5 Mitochondrial Transfer from MSCs to Injured Target Cells ... 239 8.6 Therapeutic Potential of MSC-Derived Microvesicles and Exosomes ... 239 8.7 Response of Injured Tissue and the Interplay of Microvesicles/ Exosomes Derived from Injured Tissue and MSCs ... 243 Conclusion ... 243 References ...245