Details

Autor(en) / Beteiligte

• Oliveira Cobucci, Ricardo Ney
• de Oliveira Crispim, Janaina Cristiana
• da Silveira Gonçalves, Ana Katherine
• Gupta, Satya Prakash

Titel

Prospective Therapies of Genital Human Papillomavirus Infections

Ist Teil von

• Cancer-Causing Viruses and Their Inhibitors, 2014, p.261-277

Auflage

1

Ort / Verlag

United Kingdom: CRC Press

Erscheinungsjahr

2014

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Genital infection by human papillomavirus (HPV) is the most common sexually transmitted disease in the world. Its global prevalence among women without cervical abnormalities is 12%, with higher rates in Africa (24%), Eastern Europe (21%), and Latin America (16%). HPV infection is related to six types of carcinomas: cervix, penis, vulva, vagina, anus, and oropharynx. All HPVs have a special affinity for epithelial cells, and infection persists in the dividing basal cells of the cutaneous or mucosal epithelium. HPV gains access to host cells through microabrasions in the epithelium. HPV infection is considered to be latent when the virus can only be detected by sensitive molecular methods in an otherwise normal epithelium without any cytological, morphological, or colposcopic alterations. Progress in developing effective therapies for HPV infection has been slow, mainly due to difficulties in studying the biology and pathogenesis of these viruses, which have a unique and complex replication cycle.