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Multiple Bcl-2 Family Members Demonstrate Selective Dimerizations with Bax
Ist Teil von
Proceedings of the National Academy of Sciences - PNAS, 1995-08, Vol.92 (17), p.7834-7838
Ort / Verlag
United States: National Academy of Sciences of the United States of America
Erscheinungsjahr
1995
Quelle
MEDLINE
Beschreibungen/Notizen
A family of Bcl-2-related proteins regulates cell death and shares highly conserved BH1 and BH2 domains. BH1 and BH2 domains of Bcl-2 were required for it to heterodimerize with Bax and to repress apoptosis. A yeast two-hybrid assay accurately reproduced this interaction and defined a selectivity and hierarchy of further dimerizations. Bax also heterodimerizes with Bcl-XL, Mcl-1, and A1. A Gly-159 → Ala substitution in BH1 of Bcl-xLdisrupted its heterodimerization with Bax and abrogated its inhibition of apoptosis in mammalian cells. This suggests that the susceptibility to apoptosis is determined by multiple competing dimerizations in which Bax may be a common partner.