Details

Autor(en) / Beteiligte

• Fultz, Patricia N.
• McClure, Harold M.
• Anderson, Daniel C.
• Swenson, R. Brent
• Anand, Rita
• Srinivasan, A.

Titel

Isolation of a T-Lymphotropic Retrovirus from Naturally Infected Sooty Mangabey Monkeys (Cercocebus atys)

Ist Teil von

• Proceedings of the National Academy of Sciences - PNAS, 1986-07, Vol.83 (14), p.5286-5290

Ort / Verlag

Washington, DC: National Academy of Sciences of the United States of America

Erscheinungsjahr

1986

Quelle

MEDLINE

Beschreibungen/Notizen

• Healthy mangabey monkeys in a colony at the Yerkes Regional Primate Research Center were found to be infected with a retrovirus related to human immunodeficiency virus (HIV). Virus was isolated from peripheral blood cells of 14 of 15 randomly selected mangabeys. All virus-positive animals had antibodies to the mangabey virus at the time of virus isolation and, in a retrospective study, 82% of mangabey serum samples obtained in 1981 had antibodies to the virus. The newly isolated retrovirus is (i) morphologically identical to HIV by electron microscopy; (ii) serologically related to the human virus by enzyme immunoassay, immunoblotting experiments, radioimmunoprecipitation, and neutralization; and (iii) cytopathic for human OKT4+ cells. The mangabey virus also shares these properties with the simian T-lymphotropic virus type III (STLV-III) recently isolated from diseased macaques and from healthy African green monkeys (STLV-IIIAGM). However, the mangabey virus, like STLV-IIIAGM, differs from both HIV and STLV-III in that it apparently does not cause clinical immunodeficiency or disease following natural infection of the host from which it was isolated. Comparison of the virus-host interactions of these isolates may be valuable in defining determinants of pathogenicity for cytopathic retroviruses.