Details

Autor(en) / Beteiligte

• Reddick, Robert L.
• Griggs, Thomas R.
• Lamb, Mary Ann
• Brinkhous, Kenneth M.

Titel

Platelet Adhesion to Damaged Coronary Arteries: Comparison in Normal and Von Willebrand Disease Swine

Ist Teil von

• Proceedings of the National Academy of Sciences - PNAS, 1982-08, Vol.79 (16), p.5076-5079

Ort / Verlag

United States: National Academy of Sciences of the United States of America

Erscheinungsjahr

1982

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• The early response to coronary artery injury was investigated in normal swine and in swine with von Willebrand disease (vWD). Thirty minutes after coronary endothelial denudation, a monolayer of platelets was adherent to areas of simple injury in both bleeder and normal swine. The number of adherent platelets was not significantly different in the two phenotypes. Injury involving the media of the vessel produced platelet-fibrin thrombi. Platelet activation, as judged by pseudopod formation and platelet spreading over areas of simple injury, was significantly less in bleeder animals than in normal animals. These studies suggest that chemotaxis and initial contact adhesion of platelets to injured arterial wall is independent of the von Willebrand factor. On the other hand, the spreading and activation of platelets on the subendothelium appear to be dependent on the presence of plasma von Willebrand factor. Through this mechanism von Willebrand factor may contribute to arterial thrombosis and atherogenesis.