Proceedings of the National Academy of Sciences - PNAS, 2014-06, Vol.111 (24), p.8961-8966
2014
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Protons are a neurotransmitter that regulates synaptic plasticity in the lateral amygdala
- Ist Teil von
- Proceedings of the National Academy of Sciences - PNAS, 2014-06, Vol.111 (24), p.8961-8966
- Ort / Verlag
- United States: National Academy of Sciences
- Erscheinungsjahr
- 2014
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Stimulating presynaptic terminals can increase the proton concentration in synapses. Potential receptors for protons are acid-sensing ion channels (ASICs), Na ⁺- and Ca ²⁺-permeable channels that are activated by extracellular acidosis. Those observations suggest that protons might be a neurotransmitter. We found that presynaptic stimulation transiently reduced extracellular pH in the amygdala. The protons activated ASICs in lateral amygdala pyramidal neurons, generating excitatory postsynaptic currents. Moreover, both protons and ASICs were required for synaptic plasticity in lateral amygdala neurons. The results identify protons as a neurotransmitter, and they establish ASICs as the postsynaptic receptor. They also indicate that protons and ASICs are a neurotransmitter/receptor pair critical for amygdala-dependent learning and memory.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0027-8424eISSN: 1091-6490DOI: 10.1073/pnas.1407018111Titel-ID: cdi_pnas_primary_111_24_8961
- Format
- –
- Schlagworte
- Acid Sensing Ion Channel Blockers - chemistry, Acid Sensing Ion Channels - genetics, Acidosis, Amygdala, Amygdala - metabolism, Amygdala - physiology, Animals, Biological Sciences, Brain, Brain - metabolism, Electrodes, Excitatory Postsynaptic Potentials, Hydrogen-Ion Concentration, Ion channels, Ion Channels - chemistry, Learning, Long term potentiation, Memory, Mice, Mice, Inbred C57BL, Mice, Transgenic, Neuronal Plasticity, Neurons, Neurons - metabolism, Neurotransmitter Agents - metabolism, Neurotransmitters, Organ Culture Techniques, Patch-Clamp Techniques, Peptides - chemistry, Protons, Receptors, Spider Venoms - chemistry, Synapses, Synapses - physiology