Proceedings of the National Academy of Sciences - PNAS, 2009-08, Vol.106 (32), p.13463-13468
2009
Details
- Autor(en) / Beteiligte
- Titel
- IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells
- Ist Teil von
- Proceedings of the National Academy of Sciences - PNAS, 2009-08, Vol.106 (32), p.13463-13468
- Ort / Verlag
- United States: National Academy of Sciences
- Erscheinungsjahr
- 2009
- Link zum Volltext
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- Expression of T1ST2, the IL-33R, by Th2 cells requires GATA3. Resting Th2 cells express little GATA3, which is increased by IL-33 and a STAT5 activator, in turn increasing T1ST2 from its low-level expression on resting Th2 cells. Th2 cells that have upregulated T1ST2 produce IL-13, but not IL-4, in response to IL-33 plus a STAT5 activator in an antigen-independent, NF-κB-dependent, cyclosporin A (CsA)-resistant manner. Similarly, Th17 cells produce IL-17A in response to IL-1β and a STAT3 activator and Th1 cells produce IFNγ in response to IL-18 and a STAT4 inducer. Thus, each effector Th cell produces cytokines without antigenic stimulation in response to an IL-1 family member and a specific STAT activator, implying an innate mechanism through which memory CD4 T cells are recruited by an induced cytokine environment.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0027-8424eISSN: 1091-6490DOI: 10.1073/pnas.0906988106Titel-ID: cdi_pnas_primary_106_32_13463_fulltext
- Format
- –
- Schlagworte
- Allergies, Animals, Biological Sciences, Cells, Cultured, Cultured cells, Cytokines, Cytokines - biosynthesis, Family members, GATA3 Transcription Factor - metabolism, Interleukin-1 - metabolism, Interleukin-13 - metabolism, Interleukin-17 - metabolism, Interleukin-2 - biosynthesis, Interleukin-33, Interleukin-4 - metabolism, Interleukins, Interleukins - metabolism, Messenger RNA, Mice, NF-kappa B - metabolism, NFATC Transcription Factors - metabolism, p38 Mitogen-Activated Protein Kinases - metabolism, Phosphorylation, Receptors, Receptors, Antigen, T-Cell - metabolism, Receptors, Interleukin-1 - metabolism, rev genes, STAT Transcription Factors - metabolism, STAT5 Transcription Factor - metabolism, T lymphocytes, Th1 Cells - metabolism, Th2 Cells - metabolism, Up regulation