Details

Autor(en) / Beteiligte

• Dinoso, J.B
• Kim, S.Y
• Wiegand, A.M
• Palmer, S.E
• Gange, S.J
• Cranmer, L
• O'Shea, A
• Callender, M
• Spivak, A
• Brennan, T
• Kearney, M.F
• Proschan, M.A
• Mican, J.M
• Rehm, C.A
• Coffin, J.M
• Mellors, J.W
• Siliciano, R.F
• Maldarelli, F

Titel

Treatment intensification does not reduce residual HIV-1 viremia in patients on highly active antiretroviral therapy

Ist Teil von

• Proceedings of the National Academy of Sciences - PNAS, 2009-06, Vol.106 (23), p.9403-9408

Ort / Verlag

United States: National Academy of Sciences

Erscheinungsjahr

2009

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• In HIV-1-infected individuals on currently recommended antiretroviral therapy (ART), viremia is reduced to <50 copies of HIV-1 RNA per milliliter, but low-level residual viremia appears to persist over the lifetimes of most infected individuals. There is controversy over whether the residual viremia results from ongoing cycles of viral replication. To address this question, we conducted 2 prospective studies to assess the effect of ART intensification with an additional potent drug on residual viremia in 9 HIV-1-infected individuals on successful ART. By using an HIV-1 RNA assay with single-copy sensitivity, we found that levels of viremia were not reduced by ART intensification with any of 3 different antiretroviral drugs (efavirenz, lopinavir/ritonavir, or atazanavir/ritonavir). The lack of response was not associated with the presence of drug-resistant virus or suboptimal drug concentrations. Our results suggest that residual viremia is not the product of ongoing, complete cycles of viral replication, but rather of virus output from stable reservoirs of infection.