Details

Autor(en) / Beteiligte

• Mori, Yoichiro
• Fishman, Glenn I.
• Peskin, Charles S.

Titel

Ephaptic Conduction in a Cardiac Strand Model with 3D Electrodiffusion

Ist Teil von

• Proceedings of the National Academy of Sciences - PNAS, 2008-04, Vol.105 (17), p.6463-6468

Ort / Verlag

United States: National Academy of Sciences

Erscheinungsjahr

2008

Quelle

MEDLINE

Beschreibungen/Notizen

• We study cardiac action potential propagation under severe reduction in gap junction conductance. We use a mathematical model of cellular electrical activity that takes into account both three-dimensional geometry and ionic concentration effects. Certain anatomical and biophysical parameters are varied to see their impact on cardiac action potential conduction velocity. This study uncovers quantitative features of ephaptic propagation that differ from previous studies based on one-dimensional models. We also identify a mode of cardiac action potential propagation in which the ephaptic and gap-junction-mediated mechanisms alternate. Our study demonstrates the usefulness of this modeling approach for electrophysiological systems especially when detailed membrane geometry plays an important role.