Proceedings of the National Academy of Sciences - PNAS, 2005-09, Vol.102 (39), p.13944-13949
2005
Details
- Autor(en) / Beteiligte
- Titel
- miR-15 and miR-16 Induce Apoptosis by Targeting BCL2
- Ist Teil von
- Proceedings of the National Academy of Sciences - PNAS, 2005-09, Vol.102 (39), p.13944-13949
- Ort / Verlag
- United States: National Academy of Sciences
- Erscheinungsjahr
- 2005
- Link zum Volltext
- Quelle
- Electronic Journals Library
- Beschreibungen/Notizen
- Chronic lymphocytic leukemia (CLL) is the most common human leukemia and is characterized by predominantly nondividing malignant B cells overexpressing the antiapoptotic B cell lymphoma 2 (Bcl2) protein. miR-15a and miR-16-1 are deleted or down-regulated in the majority of CLLs. Here, we demonstrate that miR-15a and miR-16-1 expression is inversely correlated to Bcl2 expression in CLL and that both microRNAs negatively regulate Bcl2 at a posttranscriptional level. BCL2 repression by these microRNAs induces apoptopsis in a leukemic cell line model. Therefore, miR-15 and miR-16 are natural antisense Bcl2 interactors that could be used for therapy of Bcl2-overexpressing tumors.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0027-8424eISSN: 1091-6490DOI: 10.1073/pnas.0506654102Titel-ID: cdi_pnas_primary_102_39_13944_fulltext
- Format
- –
- Schlagworte
- Apoptosis, Apoptosis - genetics, B lymphocytes, Biological Sciences, Cancer, Cell lines, Cell Proliferation, Chronic lymphocytic leukemia, Gene expression, Gene Expression Regulation, Leukemic, Genetics, Humans, Leukemia, Leukemia, Lymphocytic, Chronic, B-Cell - genetics, Leukemia, Lymphocytic, Chronic, B-Cell - metabolism, Messenger RNA, MicroRNA, MicroRNAs - genetics, MicroRNAs - physiology, Proto-Oncogene Proteins c-bcl-2 - genetics, Proto-Oncogene Proteins c-bcl-2 - metabolism, T lymphocytes, Transcription, Genetic, Transfection, Tumors