Details

Autor(en) / Beteiligte

• Chávez, Enrique
• Aparicio-Cadena, Alejandro Rusbel
• Velasco-Loyden, Gabriela
• Lozano-Rosas, María Guadalupe
• Domínguez-López, Mariana
• Cancino-Bello, Amairani
• Torres, Nimbe
• Tovar, Armando R
• Cabrera-Aguilar, Alejandro
• Chagoya-de Sánchez, Victoria
• Takahashi, Nobuyuki

Titel

An adenosine derivative prevents the alterations observed in metabolic syndrome in a rat model induced by a rich high-fat diet and sucrose supplementation

Ist Teil von

• PloS one, 2023-10, Vol.18 (10), p.e0292448-e0292448

Ort / Verlag

San Francisco: Public Library of Science

Erscheinungsjahr

2023

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Metabolic syndrome is a multifactorial disease with high prevalence worldwide. It is related to cardiovascular disease, diabetes, and obesity. Approximately 80% of patients with metabolic syndrome have some degree of fatty liver disease. An adenosine derivative (IFC-305) has been shown to exert protective effects in models of liver damage as well as on elements involved in central metabolism; therefore, here, we evaluated the effect of IFC-305 in an experimental model of metabolic syndrome in rats induced by a high-fat diet and 10% sucrose in drinking water for 18 weeks. We also determined changes in fatty acid uptake in the Huh-7 cell line. In the experimental model, increases in body mass, serum triglycerides and proinflammatory cytokines were induced in rats, and the adenosine derivative significantly prevented these changes. Interestingly, IFC-305 prevented alterations in glucose and insulin tolerance, enabling the regulation of glucose levels in the same way as in the control group. Histologically, the alterations, including mitochondrial morphological changes, observed in response to the high-fat diet were prevented by administration of the adenosine derivative. This compound exerted protective effects against metabolic syndrome, likely due to its action in metabolic regulation, such as in the regulation of glucose blood levels and hepatocyte fatty acid uptake.