Details

Autor(en) / Beteiligte

• Sarikaya Bayram, Özlem
• Bayram, Özgür
• Karahoda, Betim
• Meister, Cindy
• Köhler, Anna M
• Thieme, Sabine
• Elramli, Nadia
• Frawley, Dean
• McGowan, Jamie
• Fitzpatrick, David A
• Schmitt, Kerstin
• de Assis, Leandro Jose
• Valerius, Oliver
• Goldman, Gustavo H
• Braus, Gerhard H

Titel

F-box receptor mediated control of substrate stability and subcellular location organizes cellular development of Aspergillus nidulans

Ist Teil von

• PLoS genetics, 2022-12, Vol.18 (12), p.e1010502-e1010502

Ort / Verlag

United States: Public Library of Science

Erscheinungsjahr

2022

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Fungal growth and development are coordinated with specific secondary metabolism. This coordination requires 8 of 74 F-box proteins of the filamentous fungus Aspergillus nidulans. F-box proteins recognize primed substrates for ubiquitination by Skp1-Cul1-Fbx (SCF) E3 ubiquitin RING ligases and degradation by the 26S proteasome. 24 F-box proteins are found in the nuclear fraction as part of SCFs during vegetative growth. 43 F-box proteins interact with SCF proteins during growth, development or stress. 45 F-box proteins are associated with more than 700 proteins that have mainly regulatory roles. This corroborates that accurate surveillance of protein stability is prerequisite for organizing multicellular fungal development. Fbx23 combines subcellular location and protein stability control, illustrating the complexity of F-box mediated regulation during fungal development. Fbx23 interacts with epigenetic methyltransferase VipC which interacts with fungal NF-κB-like velvet domain regulator VeA that coordinates fungal development with secondary metabolism. Fbx23 prevents nuclear accumulation of methyltransferase VipC during early development. These results suggest that in addition to their role in protein degradation, F-box proteins also control subcellular accumulations of key regulatory proteins for fungal development.