Details

Autor(en) / Beteiligte

• Moal, Bertrand
• Orieux, Arthur
• Ferté, Thomas
• Neuraz, Antoine
• Brat, Gabriel A
• Avillach, Paul
• Bonzel, Clara-Lea
• Cai, Tianxi
• Cho, Kelly
• Cossin, Sébastien
• Griffier, Romain
• Hanauer, David A
• Haverkamp, Christian
• Ho, Yuk-Lam
• Hong, Chuan
• Hutch, Meghan R
• Klann, Jeffrey G
• Le, Trang T
• Loh, Ne Hooi Will
• Luo, Yuan
• Makoudjou, Adeline
• Morris, Michele
• Mowery, Danielle L
• Olson, Karen L
• Patel, Lav P
• Samayamuthu, Malarkodi J
• Sanz Vidorreta, Fernando J
• Schriver, Emily R
• Schubert, Petra
• Verdy, Guillaume
• Visweswaran, Shyam
• Wang, Xuan
• Weber, Griffin M
• Xia, Zongqi
• Yuan, William
• Zhang, Harrison G
• Zöller, Daniela
• Kohane, Isaac S
• Boyer, Alexandre
• Jouhet, Vianney
• Chen, Robert Jeenchen

Titel

Acute respiratory distress syndrome after SARS-CoV-2 infection on young adult population: International observational federated study based on electronic health records through the 4CE consortium

Ist Teil von

• PloS one, 2023-01, Vol.18 (1), p.e0266985

Ort / Verlag

United States: Public Library of Science

Erscheinungsjahr

2023

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• In young adults (18 to 49 years old), investigation of the acute respiratory distress syndrome (ARDS) after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been limited. We evaluated the risk factors and outcomes of ARDS following infection with SARS-CoV-2 in a young adult population. A retrospective cohort study was conducted between January 1st, 2020 and February 28th, 2021 using patient-level electronic health records (EHR), across 241 United States hospitals and 43 European hospitals participating in the Consortium for Clinical Characterization of COVID-19 by EHR (4CE). To identify the risk factors associated with ARDS, we compared young patients with and without ARDS through a federated analysis. We further compared the outcomes between young and old patients with ARDS. Among the 75,377 hospitalized patients with positive SARS-CoV-2 PCR, 1001 young adults presented with ARDS (7.8% of young hospitalized adults). Their mortality rate at 90 days was 16.2% and they presented with a similar complication rate for infection than older adults with ARDS. Peptic ulcer disease, paralysis, obesity, congestive heart failure, valvular disease, diabetes, chronic pulmonary disease and liver disease were associated with a higher risk of ARDS. We described a high prevalence of obesity (53%), hypertension (38%- although not significantly associated with ARDS), and diabetes (32%). Trough an innovative method, a large international cohort study of young adults developing ARDS after SARS-CoV-2 infection has been gather. It demonstrated the poor outcomes of this population and associated risk factor.