PLoS genetics, 2022-10, Vol.18 (10), p.e1010488
2022
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- Autor(en) / Beteiligte
- Titel
- Exon-dependent transcriptional adaptation by exon-junction complex proteins Y14/RNP-4 and MAGOH/MAG-1 in Caenorhabditis elegans
- Ist Teil von
- PLoS genetics, 2022-10, Vol.18 (10), p.e1010488
- Ort / Verlag
- United States: Public Library of Science
- Erscheinungsjahr
- 2022
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Transcriptional adaptation is a powerful gene regulation mechanism that can increase genetic robustness. Transcriptional adaptation occurs when a gene is mutated and is mediated by the mutant RNA, rather than by protein feedback loops. We show here that transcriptional adaptation occurs in the C. elegans clh family of Cl- channels and that it requires exon-junction complex (EJC) proteins RNP-4, MAG-1, and eiF4AIII. Depending on which exons are deleted in distinct clh-1 alleles, different clh genes are regulated in an EJC-dependent manner. Our results support the idea that different transcriptional adaptation outcomes may be directed by the differential interaction of the EJC with its target mutant RNAs.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1553-7404, 1553-7390eISSN: 1553-7404DOI: 10.1371/journal.pgen.1010488Titel-ID: cdi_plos_journals_2737134675
- Format
- –
- Schlagworte
- Adaptation, Adaptation (Biology), Animals, Biology and life sciences, Caenorhabditis elegans - genetics, Caenorhabditis elegans - metabolism, Caenorhabditis elegans Proteins - genetics, Caenorhabditis elegans Proteins - metabolism, Cell Nucleus - metabolism, Cellular proteins, Chloride channels, Chloride Channels - genetics, Chromosomes, Exons, Exons - genetics, Gene expression, Gene regulation, Genetic research, Genetic transcription, Medicine and Health Sciences, Mutants, Mutation, Nematodes, Observations, Properties, Proteins, Research and Analysis Methods, RNA - metabolism, RNA Splicing - genetics, RNA, Messenger - genetics, RNA-Binding Proteins - genetics, Transcription