Details

Autor(en) / Beteiligte

• Moll, Sofia A
• Platenburg, Mark G. J. P
• Platteel, Anouk C. M
• Vorselaars, Adriane D. M
• Janssen Bonàs, Montse
• Kraaijvanger, Raisa
• Roodenburg-Benschop, Claudia
• Meek, Bob
• van Moorsel, Coline H. M
• Grutters, Jan C
• Prasse, Antje

Titel

Prevalence and clinical associations of myositis antibodies in a large cohort of interstitial lung diseases

Ist Teil von

• PloS one, 2022-11, Vol.17 (11), p.e0277007-e0277007

Ort / Verlag

San Francisco: Public Library of Science

Erscheinungsjahr

2022

Quelle

EZB Free E-Journals

Beschreibungen/Notizen

• Serologic testing for autoantibodies is recommended in interstitial lung diseases (ILDs), as connective tissue diseases (CTDs) are an important secondary cause. Myositis antibodies are associated with CTD-ILD, but clinical associations with other ILDs are unclear. In this study, associations of myositis antibodies in various ILDs were evaluated. 1463 ILD patients and 116 healthy subjects were screened for myositis antibodies with a line-blot assay on serum available at time of diagnosis. Additionally, bronchoalveolar lavage fluid (BALf) was analysed. A total of 394 patients demonstrated reactivity to at least one antibody, including anti-Ro52 (36.0%), anti-Mi-2[beta] (17.3%) and anti-Jo-1 (10.9%). Anti-Jo-1 (OR 6.4; p<0.100) and anti-Ro52 (OR 6.0; p<0.001) were associated with CTD-ILD. Interestingly, anti-Mi-2[beta] was associated with idiopathic pulmonary fibrosis (IPF; OR 5.3; p = 0.001) and hypersensitivity pneumonitis (HP; OR 5.9; p<0.001). Furthermore, anti-Mi-2[beta] was strongly associated with a histological usual interstitial pneumonia (UIP) pattern (OR 6.5; p < 0.001). Moreover, anti-Mi-2[beta] reactivity was identified in BALf and correlated with serum anti-Mi-2[beta] (r = 0.64; p = 0.002). No differences were found in survival rates between ILD patients with and without serum Mi-2[beta] reactivity (hazard ratio 0.835; 95% CI 0.442-1.575; p = 0.577). In conclusion, novel associations of antibody Mi-2[beta] with fibrotic ILD were found. Furthermore, serum anti-Mi-2[beta] was associated with a histological UIP pattern and presence of anti-Mi-2[beta] in BALf. Possibly, anti-Mi-2[beta] could be implemented as a future diagnostic biomarker for fibrotic ILD.