Details

Autor(en) / Beteiligte

• Cherenack, Emily M
• Salazar, Ana S
• Nogueira, Nicholas F
• Raccamarich, Patricia
• Rodriguez, Violeta J
• Mantero, Alejandro M
• Marsh, Allison
• Gerard, Sophia
• Maddalon, Marissa
• Jones, Deborah L
• Klatt, Nichole R
• Alcaide, Maria L
• Njenga, M. Kariuki

Titel

Infection with SARS-CoV-2 is associated with menstrual irregularities among women of reproductive age

Ist Teil von

• PloS one, 2022-10, Vol.17 (10), p.e0276131-e0276131

Ort / Verlag

United States: Public Library of Science

Erscheinungsjahr

2022

Quelle

MEDLINE

Beschreibungen/Notizen

• Biological and psychological mechanisms may be responsible for menstrual irregularities occurring among women during the COVID-19 pandemic. From January 2019 to September 2021, women (18- to 45-years-old and not using hormonal contraception) were recruited in Miami-Dade County, Florida. Cross-sectional, self-report surveys collected data on menstrual irregularities, COVID-19 vaccination, stress, depression, and loneliness. A EUA approved rapid test assay using whole blood measured SARS-CoV-2 IgG antibodies. Chi-square and Fisher's exact tests described menstrual irregularities among women recruited before versus after the start of the COVID-19 pandemic and with detectable versus undetectable SARS-CoV-2 IgG antibodies. A logistic regression examined the relationship between the presence of SARS-CoV-2 IgG antibodies and menstrual irregularities controlling for age, stress, depression, and loneliness. Among 182 women enrolled, 73 were enrolled after pandemic onset, and 36 provided vaccination data. Having detectable SARS-CoV-2 IgG antibodies was associated with a higher percentage of menstrual irregularities among unvaccinated women (0% vs. 39%, p = .026) and among all women regardless of vaccination status (31% vs. 5%; p = .005). Adjusting for age and psychological variables, the odds of menstrual irregularities were 7.03 times (95% CI [1.39, 35.60]; p = .019) higher among women with detectable antibodies compared to women without detectable antibodies. Neither enrollment date, age, nor psychological factors were associated to menstrual irregularities. Biological mechanisms related to SARS-CoV-2 infection may be responsible for irregular menstruation and should be further examined to mitigate the impact of the COVID-19 pandemic on women's health.